Some of the Trial Participation and Research Contributions by Dr. Espinoza and his team
Cardiology Studies
- NHI BEST CLI Trial – Best Endovascular vs. Best Surgical Therapy in Patients With Critical Limb Ischemia (BEST-CLI)
November 7, 2022, N Engl J Med 2022;387:2305-2316 - THEMIS Clinical Trial – A Study Comparing Cardiovascular Effects of Ticagrelor Versus Placebo in Patients With Type 2 Diabetes Mellitus (THEMIS)
September 1, 2019, - N Engl J Med 2019;381:1309-1320 – Ticagrelor in Patients with Stable Coronary Disease and Diabetes
- ODYSSEY OUTCOMES Trial – ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab, November 7, 2018
- N Engl J Med 2018;379:2097-2107
JACC Cardiovasc Interv 2018;11(10):921-931 – Adventitial Drug Delivery of Dexamethasone to Improve Primary Patency in the Treatment of Superficial Femoral and Popliteal Artery Disease: 12-Month Results From the DANCE Clinical Trial - EUCLID Study N Engl J Med 2017;376:32-40 – Ticagrelor versus Clopidogrel in Symptomatic Peripheral Artery Disease
- SOCRATES Trial N Engl J Med 2016;375:35-43 – Ticagrelor versus Aspirin in Acute Stroke or Transient Ischemic Attack
- HCRI DAPT – The Dual Antiplatelet Therapy Study (DAPT Study)
N Engl J Med 2014;371:2155-2166 - SYMPLICITY HTN-3 – A Controlled Trial of Renal Denervation for Resistant Hypertension
N Engl J Med 2014;370:1393-1401 - ORBIT AF II – Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF)
- ZESCA Study (Investigational Drug)
J Am Coll Cardiol 2013;61(5):524-32 - TRILOGY ACS Study – A Comparison of Prasugrel and Clopidogrel in Acute Coronary Syndrome Subjects (TRILOGY ACS)
N Engl J Med 2012;367:1297-1309 - FREEDOM Trial – Strategies for Multivessel Revascularization in Patients with Diabetes
N Engl J Med 2012;367:2375-2384
Interventional Studies
- LUCY Study
Journal of Vascular Surgery
Vol. 72, Issue 2, August 2020, Pages 566-575.e4 - DANCE Trial Presented at Leipzig and ISET conferences
- SAFE-PCI Trial JACC Cardiovasc Interv
2014 Aug; 7(8):857-67 - OSPREY Study – A Multi-center Clinical Trial of the Misago™ Self-Expanding Stent System for Superficial Femoral Artery (OSPREY)
J Vasc Surg 2016;63(2):370-376.e1 - SUPERB Study – Comparison of the SUpera® PERipheral System in the Superficial Femoral Artery (SUPERB)
Circ Cardiovasc Interv. 2015;8:e000937 - EXACT Study PMA of Carotid Stent
- CORAL Trial – Benefits of Medical Therapy Plus Stenting for Renal Atherosclerotic Lesions (CORAL)
N Engl J Med 2014;370:13-22 - MOBILITY SFA Stent Trial
- PROTECT II Study – Protect II, A Prospective, Multicenter Randomized Controlled Trial (PROTECT II)
Circulation Oct 2, 2012, Vol 126, Issue 14 – A Prospective, Randomized Clinical Trial of Hemodynamic Support With Impella 2.5 Versus Intra-Aortic Balloon Pump in Patients Undergoing High-Risk Percutaneous Coronary Intervention: The PROTECT II Study - TRACER Study – Trial to Assess the Effects of Vorapaxar (SCH 530348; MK-5348) in Preventing Heart Attack and Stroke in Patients With Atherosclerosis (TRA 2°P – TIMI 50) (P04737)
N Engl J Med 2012;366:1404-1413 - CAPTURE II Study: PMA Study of Carotid Stenting – CAPTURE 2 risk-adjusted stroke outcome benchmarks for carotid artery stenting with distal embolic protection
J Am Coll Cardiol Intv. 2011;4(2):235-246 - SAPPHIRE WW: PMA Study of Carotid Stenting – Stenting and angioplasty with protection in patients at high-risk for endarterectomy: SAPPHIRE Worldwide Registry first 2,001 patients
CCI First 2001 Patients Published Volume 73, Issue 2, Oct 15, 2008
Endovascular Studies
- VOYAGER PAD Trial – Efficacy and Safety of Rivaroxaban in Reducing the Risk of Major Thrombotic Vascular Events in Subjects With Symptomatic Peripheral Artery Disease Undergoing Peripheral Revascularization Procedures of the Lower Extremities (VOYAGER PAD)
N Engl J Med 2020;382:1994-2004 - DANCE Trial – Effectiveness of Adventitial Dexamethasone in Peripheral Artery Disease (DANCE)
JACC Cardiovasc Interv 2018;11(10):921-931 - CHOCOLATE BAR Registry – Chocolate Balloon Angioplasty Registry (Chocolate BAR)
Catheter Cardiovasc Interv 2018;91(6):1144-1148 - SUPERB Study – Comparison of the SUpera® PERipheral System in the Superficial Femoral Artery (SUPERB)
Circ Cardiovasc Interv. 2015;8:e000937- - BioMimics 3D: MIMICS-2 Trial – Evaluation of Safety and Effectiveness of the BioMimics 3D Stent System (MIMICS-2)
Journal of Endovascular Therapy, Dec 17, 2020 - OSPREY Study – A Multi-center Clinical Trial of the Misago™ Self-Expanding Stent System for Superficial Femoral Artery (OSPREY)
J Vasc Surg Feb 2016; 63(2):370-376.e1- - DEFINITIVE LE – Lower extremity revascularization using directional atherectomy: 12-month prospective results of the DEFINITIVE LE study
JACC Cardiovasc Interv 2014 Aug; 7(8):923-33 - LEVANT I Trial – Outcomes of Anatomical versus Functional Testing for Coronary Artery Disease
JACC Cardiovasc Interv 2014 Jan; 7(1):10-9 - EASE Study – Endovascular Atherectomy Safety and Effectiveness Study (EASE)