Learn About The CCTA

Discover What Your Heart May Be Telling You — Earlier

Heart disease can develop years before symptoms appear. Many people feel healthy while plaque is quietly building inside the arteries that supply blood to the heart.

The TRANSFORM Trial (Cleerly) is a research study exploring whether advanced heart imaging and artificial intelligence can help doctors detect coronary artery disease earlier and more precisely.

Using technology developed by Cleerly, this study analyzes plaque buildup in the coronary arteries. Plaque is a fatty substance that can narrow or block arteries and increase the risk of heart attack and other cardiovascular events.

Why Early Detection Matters

Many people who develop heart disease have common health conditions that increase cardiovascular risk. These risk factors can affect the heart long before symptoms begin.

Some of the most important risk factors include:

  • Diabetes
  • Prediabetes
  • High cholesterol
  • High blood pressure
  • Family history of heart disease
  • Smoking
  • Overweight or obesity
  • Sedentary lifestyle

Conditions like diabetes and prediabetes can damage blood vessels over time, increasing the likelihood of plaque buildup and coronary artery disease. Unfortunately, traditional risk assessments may not always detect early disease in these patients.


A New Approach to Understanding Heart Risk

The TRANSFORM Trial is studying whether AI-assisted coronary CT imaging can help physicians:

  • Detect hidden plaque earlier
  • Identify patients who may be at higher risk
  • Better understand how conditions like diabetes affect heart health
  • Personalize prevention and treatment strategies
  • Reduce the likelihood of future heart attacks or cardiac events

By combining advanced imaging with modern technology, researchers hope to shift care from reactive treatment after a heart event to proactive prevention before one occurs.

Interested in Learning More?

You may qualify to learn more about this research study if you have risk factors such as diabetes or prediabetes or want to better understand your heart health.

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View Study on ClinicalTrials.gov